Contents

πŸ“’ Smith 2004

Contents

Development of models of active ion transport for whole-cell modelling: cardiac sodium-potassium pump as a case study1

Sciwheel

  • Net reaction: https://user-images.githubusercontent.com/40054455/86723117-2fd06e80-c05a-11ea-8b97-497bc2be0d16.png

  • The Na/K-ATPase is one of the P-type active cation transporters

  • Post-Albers scheme is a consecutive (β€œping-pong”) mechanism https://user-images.githubusercontent.com/40054455/86723125-319a3200-c05a-11ea-9106-a384fe89bb99.png

  • Reversal of the sodium–potassium pump has been reported for erythrocytes by manipulation of ion and metabolite concentrations to unphysiological levels

https://user-images.githubusercontent.com/40054455/86723128-3232c880-c05a-11ea-9046-8c8f796ebaa4.png https://user-images.githubusercontent.com/40054455/86723120-30690500-c05a-11ea-960a-27dfb1b9e436.png

  • the expression for Ξ±3- must also account for the equilibrium between free inorganic phosphate [Pi] and its bound species [HPi], [KPi] and [NaPi] https://user-images.githubusercontent.com/40054455/86723122-31019b80-c05a-11ea-88e7-282de8dd837f.png

https://user-images.githubusercontent.com/40054455/86723133-32cb5f00-c05a-11ea-9ef4-78678043910e.png


  1. Smith NP, Crampin EJ. Development of models of active ion transport for whole-cell modelling: cardiac sodium-potassium pump as a case study. Prog. Biophys. Mol. Biol. 2004;85(2-3):387-405. doi:10.1016/j.pbiomolbio.2004.01.010. DOI↩︎