# ðŸ“’ Saa 2013

Contents

Modeling the ATP Production in Mitochondria

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## Introduction

Bertram, Pedersen, Luciani, and Sherman (BPLS) model is the simplification of Magnus and Keizer’s with some refinements introduced by Cortassa, 2003.

- 4 state variables (NADH, ATP, Ca, Î”Î¨)
- some inaccuracies in the BPLS expressions while transcripting math expressions
- ANT: adenine nucleotide translocator
- Uni: calcium uniporter

## Methods

The issues are fixed by the authers, hence the enhanced BPLS (eBPLS) model.

- Glycolysis from fructose-1,6-bisphosphate (FBP), as a parameter to pyruvate dehydrogenase (PDH) rate
- The same 4 state variable as those of BPLS
- Normalized (dimensionless) quantities for evaluation of freqency response

### Equations

### Parameters

## Results

## Discussion and conclusion

- Simplifications from KM model, corrections for BPLS model.
- The inertia of the system tends to increase considerably for high concentrations of cytosolic calcium and FBP.

## My point of view

- Seems not so physiologically sane for the ATP level dropped to zero sometimes.

Saa A, Siqueira KM. Modeling the ATP production in mitochondria. Bull Math Biol. 2013 Sep;75(9):1636â€“51. ↩︎