Contents

📒 Kang 2004

Contents

Multiple transport modes of the cardiac Na+/Ca2+ exchanger1

Sciwheel.

NCX1 cannot generate larger Ca2+ gradients than expected for a Na+/Ca2+ transport ratio of 3:1, and that Na+ transported in excess of a 3:1 ratio moves as Ca2+-dependent Na+ slippage

3 conducting modes: 3 Na+ can exchange for 1 Ca2+, 1 Na+ and 1 Ca2+ can exchange for 1 Ca2+ (that is, a Na+-conducting mode), and 1 Ca2+ and 1 Na+ can exchange for 3 Na+ ions (that is, a net 2 Na+/1 Ca2+ exchange) https://user-images.githubusercontent.com/40054455/86699578-e7f21d00-c042-11ea-93cf-2ce7594d3636.jpg


  1. Kang TM, Hilgemann DW. Multiple transport modes of the cardiac Na+/Ca2+ exchanger. Nature 2004;427(6974):544-548. doi:10.1038/nature02271. ↩︎